Α-Χεντερίνη

Η α-χεντερίνη είναι μια υδατοδιαλυτή πεντακυκλική τριτερπενοειδής σαπωνίνη που απαντάται στους σπόρους του φυτού Nigella sativa και στα φύλλα του θάμνου Hedera helix.^[1]^[2]^[3]^[4]

Τόσο η α-χεντερίνη όσο επίσης και το παράγωγό της, η καλοπαναξοσαπονίνη, έχουν μελετηθεί για την αντικαρκινική τους δράση.^[5]^[6] Η α-χεντερίνη έχει αποδειχθεί ότι ενισχύει την κυτταροτοξικότητα ενός καθιερωμένου χημειοθεραπευτικού παράγοντα, της 5-φθοροουρακίλης, σε ένα μοντέλο καρκινώματος του παχέος εντέρου.^[5]

Παραπομπές[Επεξεργασία | επεξεργασία κώδικα]

↑ Evans, William Charles (2009). Trease and Evans' Pharmacognosy (16th έκδοση). Saunders. σελ. 322. ISBN 978-0-7020-2933-2.
↑ Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). «Nigella sativa: Reduces the risk of various maladies». Critical Reviews in Food Science and Nutrition 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. «N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).».
↑ Shafiq, Hammad; Ahmad, Asif; Masud, Tariq; Kaleem, Muhammad (2014). «Cardio-protective and anti-cancer therapeutic potential of Nigella sativa». Iranian Journal of Basic Medical Sciences 17 (12): 967–979. doi:10.22038/IJBMS.2015.3853. PMID 25859300. «N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, flavonoids, antioxidants, fatty acids many other compounds that have positive effects on curing of different diseases.».
↑ Gholamnezhad, Zahra; Havakhah, Shahrzad; Boskabady, Mohammad Hossein (2016). «Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review». Journal of Ethnopharmacology 190: 372–386. doi:10.1016/j.jep.2016.06.061. PMID 27364039. «The seeds of the plant also contain many non-oily and non-caloric components in trace amounts, including pyrazole alkaloids (nigellidine and nigellicine, Fig. 1d), isoquinoline alkaloids (nigellicimine and nigellicimine-N-oxide, Fig. 1e), alpha-hederin (a water-soluble pentacyclic triterpene, Fig. 1f), saponin (a potential anticancer agent), vitamins (riboflavin, thiamin, niacin, pyridoxine, folic acid, and vitamin E), and minerals (potassium, sodium, calcium, phosphorus, magnesium, copper, and iron) (Nergiz and Ötleş, 1993).».
↑ ^5,0 ^5,1 Randhawa, Mohammad Akram; Alghamdi, Mastour Safar. «Anticancer activity of Nigella sativa (black seed)—A review». The American Journal of Chinese Medicine 39 (6): 1075–1091. doi:10.1142/S0192415X1100941X. PMID 22083982. «A literature search has revealed that a lot more studies have been recently carried out related to the anticancer activities of N. sativa and some of its active compounds, such as thymoquinone and alpha-hederin ... Another important active compound that has been shown to possess anticancer effects is alpha-hederin, a pentacycline triterpene and a saponin, which is water soluble perhaps the major active component in the aqueous extract of N. sativa ... One of the derivatives of alpha-hederin, kalopanaxsaponin-I, was found to possess anticancer activity ... Alpha-hederin also, in sub-IC₅₀ cytotoxic concentrations, was shown to enhance the cytotoxicity of 5-fluorouracil in a human colon carcinoma model, HT-29 cells, 3.3-fold (Bun et al., 2008) ... Moreover, N. saliva seed, its oil, thymoquinone, alpha-hederin or their analogs could be used in suitable combinations with already established as chemotherapeutic agents.».
↑ Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). «Nigella sativa: Reduces the risk of various maladies». Critical Reviews in Food Science and Nutrition 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. «N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).». Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). "Nigella sativa: Reduces the risk of various maladies". Critical Reviews in Food Science and Nutrition. 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. S2CID 22905497. N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).

[1] Evans, William Charles (2009). Trease and Evans' Pharmacognosy (16th έκδοση). Saunders. σελ. 322. ISBN 978-0-7020-2933-2.

[2] Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). «Nigella sativa: Reduces the risk of various maladies». Critical Reviews in Food Science and Nutrition 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. «N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).».

[pmid25859300-3] Shafiq, Hammad; Ahmad, Asif; Masud, Tariq; Kaleem, Muhammad (2014). «Cardio-protective and anti-cancer therapeutic potential of Nigella sativa». Iranian Journal of Basic Medical Sciences 17 (12): 967–979. doi:10.22038/IJBMS.2015.3853. PMID 25859300. «N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, flavonoids, antioxidants, fatty acids many other compounds that have positive effects on curing of different diseases.».

[pmid27364039-4] Gholamnezhad, Zahra; Havakhah, Shahrzad; Boskabady, Mohammad Hossein (2016). «Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review». Journal of Ethnopharmacology 190: 372–386. doi:10.1016/j.jep.2016.06.061. PMID 27364039. «The seeds of the plant also contain many non-oily and non-caloric components in trace amounts, including pyrazole alkaloids (nigellidine and nigellicine, Fig. 1d), isoquinoline alkaloids (nigellicimine and nigellicimine-N-oxide, Fig. 1e), alpha-hederin (a water-soluble pentacyclic triterpene, Fig. 1f), saponin (a potential anticancer agent), vitamins (riboflavin, thiamin, niacin, pyridoxine, folic acid, and vitamin E), and minerals (potassium, sodium, calcium, phosphorus, magnesium, copper, and iron) (Nergiz and Ötleş, 1993).».

[pmid22083982-5] 5,0 ^5,1 Randhawa, Mohammad Akram; Alghamdi, Mastour Safar. «Anticancer activity of Nigella sativa (black seed)—A review». The American Journal of Chinese Medicine 39 (6): 1075–1091. doi:10.1142/S0192415X1100941X. PMID 22083982. «A literature search has revealed that a lot more studies have been recently carried out related to the anticancer activities of N. sativa and some of its active compounds, such as thymoquinone and alpha-hederin ... Another important active compound that has been shown to possess anticancer effects is alpha-hederin, a pentacycline triterpene and a saponin, which is water soluble perhaps the major active component in the aqueous extract of N. sativa ... One of the derivatives of alpha-hederin, kalopanaxsaponin-I, was found to possess anticancer activity ... Alpha-hederin also, in sub-IC₅₀ cytotoxic concentrations, was shown to enhance the cytotoxicity of 5-fluorouracil in a human colon carcinoma model, HT-29 cells, 3.3-fold (Bun et al., 2008) ... Moreover, N. saliva seed, its oil, thymoquinone, alpha-hederin or their analogs could be used in suitable combinations with already established as chemotherapeutic agents.».

[pmid20694927-6] Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). «Nigella sativa: Reduces the risk of various maladies». Critical Reviews in Food Science and Nutrition 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. «N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).». Butt, Masood Sadiq; Sultan, Muhammad Tauseef (2010). "Nigella sativa: Reduces the risk of various maladies". Critical Reviews in Food Science and Nutrition. 50 (7): 654–665. doi:10.1080/10408390902768797. PMID 20694927. S2CID 22905497. N. sativa seeds also contain proteins, alkaloids (nigellicines and nigelledine), and saponins (α-hederin) in substantial amounts ... Some of its components, especially α-Hederin, have shown some significant effects in mitigating the cancerous cell growth (Salem, 2005; Ramadan, 2007).

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