Υποδοχέας τρανσφερρίνης πρωτεΐνη 1

Ο υποδοχέας τρανσφερρίνης πρωτεΐνη 1 (αγγλ. transferrin receptor protein 1, ΤfR1), γνωστός και ως CD71 (εκ του Cluster of Differentiation 71) είναι μια πρωτεΐνη της κυτταρικής μεμβράνης, η οποία στον άνθρωπο κωδικοποιείται από το γονίδιο TFRC.^[1]^[2] Ο υποδοχέας τρανσφερρίνης πρωτεΐνη 1 χρησιμεύει στη μεταφορά του σιδήρου που βρίσκεται συνδεδεμένος στην πρωτεΐνη τρανσφερρίνη προς το εσωτερικό του κυττάρου.^[3]^[4]

Αλληλεπιδράσεις

Ο υποδοχέας τρανσφερρίνης πρωτεΐνη 1, εκτός της τρανσφερρίνης, έχει δειχθεί να αλληλεπιδρά και με τις πρωτεΐνες GABARAP^[5] και HFE.^[6]^[7]

Δείτε επίσης

Παραπομπές

↑ Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). «Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin». Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMID 6270680.
↑ Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). «Regional localization of the human transferrin receptor gene to 3q26.2----qter». Am. J. Hum. Genet. 37 (6): 1112–6. PMID 3002171. PMC 1684729. https://archive.org/details/sim_american-journal-of-human-genetics_1985-11_37_6/page/1112.
↑ Aisen P (November 2004). «Transferrin receptor 1». Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.
↑ Moos T (November 2002). «Brain iron homeostasis». Dan Med Bull 49 (4): 279–301. PMID 12553165.
↑ Green F, O'Hare T, Blackwell A, Enns CA (May 2002). «Association of human transferrin receptor with GABARAP». FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.
↑ Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). «The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding». Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMID 9465039.
↑ West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). «Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE». J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.

[pmid6270680-1] Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). «Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin». Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMID 6270680.

[pmid3002171-2] Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). «Regional localization of the human transferrin receptor gene to 3q26.2----qter». Am. J. Hum. Genet. 37 (6): 1112–6. PMID 3002171. PMC 1684729. https://archive.org/details/sim_american-journal-of-human-genetics_1985-11_37_6/page/1112.

[pmid15313461-3] Aisen P (November 2004). «Transferrin receptor 1». Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.

[pmid12553165-4] Moos T (November 2002). «Brain iron homeostasis». Dan Med Bull 49 (4): 279–301. PMID 12553165.

[pmid11997026-5] Green F, O'Hare T, Blackwell A, Enns CA (May 2002). «Association of human transferrin receptor with GABARAP». FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.

[pmid9465039-6] Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). «The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding». Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMID 9465039.

[pmid11027676-7] West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). «Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE». J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.

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